Publications


2017
Iwahori, S., Umaña, A.C., VanDeusen, H.R., Kalejta, R.F. (2017) Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins. J Biol Chem. PMID: 28289097 link
 
Kalejta R.F., Palmenberg, A.C. (2017) Gender parity trends for invited speakers at four prominent virology conference series. J Virol. PMID: 28592542 link

2016
Albright, E.R., Kalejta, R.F. (2016) Canonical and variant forms of histone H3 are deposited onto the human cytomegalovirus genome during lytic and latent infections. J Virol. PMID: 27605676 link
 
Lee WH, Higuchi H, Ikeda S, Macke EL, Takimoto T, Pattnaik BR, Liu C, Chu LF, Siepka SM, Krentz KJ, Rubinstein CD, Kalejta RF, Thomson JA, Mullins RF, Takahashi JS, Pinto LH, Ikeda A. (2016) Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies. eLife. PMID: 27863209 link

 
Lee, S.H., Caviness, K., Albright, E.R., Lee, J.H., Gelbmann, C.B., Rak, M., Goodrum, F., Kalejta, R.F. (2016) Long and short isoforms of the human cytomegalovirus UL138 protein silence IE1 transcription and promote latency. J Virol. 90, 9483-94 PMID: 27512069 link
 
Kalejta, R.F. (2016) Sifting and Winnowing through Human Cytomegalovirus Lytic Replication and Latency. PLoS Pathog. 12(9):e1005607. PMID: 27657905 link
 
Kuny, C.V., Kalejta, R.F. (2016) Human cytomegalovirus can procure deoxyribonucleotides for viral DNA replication in the absence of retinoblastoma protein phosphorylation. J. Virol. 90, 8634-43 PMID: 27440891link
 
2015
Lee, S.H., Albright, E.R., Lee, J-H., Jacobs, D., and Kalejta, R.F. (2015) Cellular defense against latent colonization foiled by human cytomegalovirus UL138 protein. Sci. Adv. 1(10):e1501164 PMCID: PMC4681346 pdf
 
VanDeusen, H.R., and Kalejta, R.F. (2015) Deficiencies in cellular processes modulated by the retinoblastoma protein do not account for reduced human cytomegalovirus replication in its absence. J. Virol. 89, 11965-74 PMCID: PMC4645314 pdf
 
Iwahori, S., Hakki, M., Chou, S., and Kalejta, R.F.  (2015)  Molecular determinants for the inactivation of the retinoblastoma tumor suppressor by the viral cyclin-dependent kinase UL97.  J. Biol. Chem. 290, 19666-19680  PMCID:  PMC4528131 pdf
 
VanDeusen, H.R., and Kalejta, R.F.  (2015)  The retinoblastoma tumor suppressor promotes efficient human cytomegalovirus lytic replication.  J. Virol. 89, 5012-5021  PMCID:  PMC4403481 pdf

 
2014
Winkler, L.L., and Kalejta, R.F.  (2014)  The 19S proteasome activator promotes human cytomegalovirus immediate early gene expression through proteolytic and non-proteolytic mechanisms.  J. Virol. 88, 11782-11790  PMCID: PMC4178716 pdf
 
Qin, Q., Lee, S.H., Liang, R., and Kalejta, R.F.  (2014)  Insertion of myeloid-active elements into the human cytomegalovirus major immediate early promoter is not sufficient to drive its activation upon infection of undifferentiated myeloid cells.  Virology 448C, 125-132.  PMCID: PMC3857587 pdf
 
2013 
Sun, X., Bristol, J.A., Iwahori, S., Hagemeier, S.R., Meng, Q., Barlow, E.A., Fingeroth, J.D., Tarakanova,V.L., Kalejta, R.F., and Kenney, S.C.  (2013)  Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells.  J. Virol. 87, 10126-10138.  PMCID: PMC3754017 pdf
 
Qin, Q., Penkert, R.R., and Kalejta, R.F.  (2013)  Heterologous viral promoters incorporated into the human cytomegalovirus genome are silenced during experimental latency.  J. Virol. 87, 9886-9894.  PMCID: PMC3754107pdf
 
Albright, E.R., and Kalejta, R.F.  (2013)  Myeloblastic cell lines mimic some but not all aspects of human cytomegalovirus experimental latency defined in primary CD34+ cell populations.  J. Virol. 87, 9802-9812.  PMCID: PMC3754112 pdf
 
Penkert, R.R., and Kalejta, R.F.  (2013)  Human embryonic stem cell lines model experimental human cytomegalovirus latency. mBio 4(3):e00298-13.  PMCID: PMC3663570 pdf
 
Winkler, L.L., Hwang, J., and Kalejta, R.F.  (2013)  Ubiquitin-independent proteasomal degradation of tumor suppressors by human cytomegalovirus pp71 requires the 19S regulatory particle.  J. Virol. 87, 4665-4671.  PMCID: PMC3624388 pdf
 
Kalejta, R.F.  (2013)  Pre-Immediate Early Tegument Protein Functions.  In Cytomegaloviruses: From Molecular Pathogenesis to Intervention, Volume 1, Chapter 9; M.J. Reddehase, ed. (Norfolk, UK, Caister Academic Press), pp.141-151;  PMCID: none pdf

 
2012 
Penkert, R.R., and Kalejta, R.F.  (2012)  Tale of a tegument transactivator: the past, present, and future ofHCMV pp71. Future Virology, 7, 855-869;  PMCID: PMC3558950 pdf

 
Dziurzynski, K., Cjang, S.M., Heimberger, A.B., Kalejta, R.F., McGregor Dallas, S.R., Smit, M.,
Soroceanu, L., Cobbs, C.S., and the HCMV and Gliomas Symposium.  (2012) Consensus on the role of human cytomegalovirus in glioblastoma.  Neuro Oncol. 14, 246-255.  PMCID: PMC3280809 pdf
 
Lee, S.H., Kalejta, R.F., Kerry, J., Semmes, O.J., O’Connor, C.M., Khan, Z., Garcia, B.A., Shenk, T., and Murphy, E.  (2012)  BclAF1 restriction factor is neutralized by proteasomal degradation and microRNA repression during human cytomegalovirus infection.  Proc. Natl. Acad. Sci. USA, 109, 9575-9580  PMCID: PMC3386064 pdf 
 
Ranganathan, P., Clark, P.A., Kuo, J.S., Salamat, M.S., and Kalejta, R.F.  2012.  Significant association of multiple human cytomegalovirus genomic loci with glioblastoma multiforme samples.  J. Virol. 86, 854-864 PMCID: PMC3255835. pdf
 
2011
Hwang, J., and Kalejta, R.F.  2011.  In vivo analysis of protein sumoylation induced by a viral protein: Detection of HCMV pp71-induced Daxx sumoylation  Methods 55, 160-165  PMCID: PMC3208771 pdf
 
Hwang, J., Winkler, L., and Kalejta, R.F.  (2011)  Ubiquitin-independent proteasomal degradation during oncogenic viral infections.  Biochim. Biophys. Acta 1816 (2) 147-157  PMCID:  PMC3193896 pdf
 
Penkert, R.R., and Kalejta, R. F. (2011) Tegument protein control of latent herpesvirus establishment and animation. Herpesviridae 2:3 PMCID: PMC3063196 pdf
 
Hwang, J., Saffert, R. T., and Kalejta, R. F. (2011) Elongin B-mediated epigenetic alteration of viral chromatin correlates with efficient human cytomegalovirus gene expression and replication. mBio 2(2):e00023-11.doi:10.1128/mBio.00023-11  PMCID: PMC3063379 pdf
 
2010
Kuny, C.V., Chinchilla, K., Culbertson, M.R., and Kalejta, R.F. (2010)  Cyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinases.  PLoS Pathog. 6(9): e1001092. doi10.1371/journal.ppat.1001092.  PMCID: PMC2936540 pdf
 
Penkert, R.R., and Kalejta, R.F.  (2010)  Nuclear localization of tegument-delivered pp71 in human cytomegalovirus infected cells is facilitated by one or more factor present in terminally differentiated fibroblasts.  J. Virol. 84 (19) 9853-63.  PMCID: PMC2937784 pdf
 
Saffert, R.T., Penkert, R.R., and Kalejta, R.F.  (2010)  Cellular and viral control over the initial events of human cytomegalovirus experimental latency in CD34+ cell.  J. Virol. May 5 2010; 84: (11) 5594-5604. Epub 2010 Mar 24 PMCID: PMC2876595 pdf
 
Meng Q., Hagemeier S.R., Kuny C.V., Kalejta R.F., and Kenney S.C.  Simian virus 40 T/t antigens and lamin A/C small interfering RNA rescue the phenotype of an Epstein-Barr virus protein kinase (BGLF4) mutant.  J. Virol. May 2010; 84: 4524-4533. Epub 2010 Feb 10 PMCID: PMC2863785 pdf
 
2009
Hume A.J., Kalejta R.F.  Regulation of the retinoblastoma proteins by the human herpesviruses. Cell Div. 2009  Jan 15;4:1.PMCID: PMC 2636798 pdf
 
Hwang J, Kalejta R.F., Human cytomegalovirus protein pp71 induces Daxx SUMOylation. J Virol 2009 Jul;83(13):6591-8. Epub 2009 Apr 15.PMCID: PMC 2698545 pdf
 
Kamil J.P., Hume A.J., Jurak I., Münger K., Kalejta R.F., Coen D.M. Human papillomavirus 16 E7 inactivator of retinoblastoma family proteins complements human cytomegalovirus lacking UL97 protein kinase. Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16823-8. Epub 2009 Sep 15. PMCID: PMC2757844 pdf
 
2008
Hume A.J., Finkel J.S., Kamil J.P., Coen D.M., Culbertson M.R., Kalejta R.F. Phosphorylation of retinoblastoma protein by viral protein with cyclin-dependent kinase function. Science. 2008 May 9;320(5877):797-9. PMID: 18467589 pdf
 
Kalejta R.F. Tegument proteins of human cytomegalovirus. Microbiol Mol Biol Rev. 2008 Jun;72(2):249-65, table of contents. Review. PMCID: PMC2415745 pdf
 
Kalejta R.F. Functions of human cytomegalovirus tegument proteins prior to immediate early gene expression. Curr Top Microbiol Immunol. 2008;325:101-15. Review. PMID: 18637502 pdf
 
Saffert R.T., Kalejta R.F. Promyelocytic leukemia-nuclear body proteins: herpesvirus enemies, accomplices, or both? Future Virol. 2008 May 1;3(3):265-277. PMCID: PMC2744987 pdf
 
2007
Hwang J., Kalejta R.F. Proteasome-dependent, ubiquitin-independent degradation of Daxx by the viral pp71 protein in human cytomegalovirus-infected cells. Virology. 2007 Oct 25;367(2):334-8. Epub 2007 Jun 27. PMID: 17590404 pdf
 
Saffert R.T., Kalejta R.F. Human cytomegalovirus gene expression is silenced by Daxx-mediated intrinsic immune defense in model latent infections established in vitro. J Virol. 2007 Sep;81(17):9109-20. Epub 2007 Jun 27.PMCID: PMC1951389 pdf
 
2006
Saffert R.T., Kalejta R.F. Inactivating a cellular intrinsic immune defense mediated by Daxx is the mechanism through which the human cytomegalovirus pp71 protein stimulates viral immediate-early gene expression. J Virol. 2006 Apr;80(8):3863-71. PMCID: PMC 1440479 pdf
 
2004
Kalejta R.F. Human cytomegalovirus pp71: a new viral tool to probe the mechanisms of cell cycle progression and oncogenesis controlled by the retinoblastoma family of tumor suppressors. J Cell Biochem. 2004 Sep 1;93(1):37-45. Review. PMID: 15352160 pdf
 
Postdoc
Kalejta R.F., Shenk T. The human cytomegalovirus UL82 gene product (pp71) accelerates progression through the G1 phase of the cell cycle.J Virol. 2003 Mar;77(6):3451-9. PMCID: PMC149542 pdf
 
Kalejta R.F., Shenk T. Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein. Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3263-8. Epub 2003 Mar 7. PMCID: PMC152280 pdf
 
Kalejta R.F., Bechtel J.T., Shenk T. Human cytomegalovirus pp71 stimulates cell cycle progression by inducing the proteasome-dependent degradation of the retinoblastoma family of tumor suppressors. Mol Cell Biol. 2003 Mar;23(6):1885-95. PMCID: PMC149485 pdf
 
Kalejta R.F., Shenk T. Manipulation of the cell cycle by human cytomegalovirus. Front Biosci. 2002 Jan 1;7:d295-306. Review. PMID: 11779699 pdf
 
Tao W., Pennica D., Xu L., Kalejta R.F., Levine A. J. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev. 2001 Jul 15;15(14):1796-807. PMCID: PMC312736 pdf
 
Beavis A.J., Kalejta R.F. Simultaneous analysis of the cyan, yellow and green fluorescent proteins.Current Protocols in Cytometry. 2001 1.16.1-1.16.12 pdf
 
Beavis A.J., Kalejta R.F. Simultaneous analysis of the cyan, yellow and green fluorescent proteins by flow cytometry using single-laser excitation at 458 nm. Cytometry. 1999 Sep 1;37(1):68-73. PMID: 10451508 pdf
 
Kalejta R.F., Brideau A.D., Banfield B.W., Beavis A.J. An integral membrane green fluorescent protein marker, Us9-GFP, is quantitatively retained in cells during propidium iodide-based cell cycle analysis by flow cytometry. Exp Cell Res. 1999 Apr 10;248(1):322-8. PMID: 10094838 pdf
 
Kalejta R.F., Shenk T., Beavis A.J. Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry. Cytometry. 1997 Dec 1;29(4):286-91. PMID: 9415410 pdf
 
Graduate
Kalejta R.F., Li X., Mesner L.D., Dijkwel P.A., Lin H.B., Hamlin J.L. Distal sequences, but not ori-beta/OBR-1, are essential for initiation of DNA replication in the Chinese hamster DHFR origin. Mol Cell. 1998 Dec;2(6):797-806. PMID: 9885567 pdf
 
Kalejta R.F., Hamlin J.L. The dual effect of mimosine on DNA replication. Exp Cell Res. 1997 Feb 25;231(1):173-83. PMID: 9056424 pdf
 
Kalejta R.F., Hamlin J.L. Composite patterns in neutral/neutral two-dimensional gels demonstrate inefficient replication origin usage. Mol Cell Biol. 1996 Sep;16(9):4915-22. PMCID: PMC231493 pdf
 
Kalejta R.F., Lin H.B., Dijkwel P.A., Hamlin J.L. Characterizing replication intermediates in the amplified CHO dihydrofolate reductase domain by two novel gel electrophoretic techniques. Mol Cell Biol. 1996 Sep;16(9):4923-31. PMCID: PMC231494 pdf